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The BRAINTRAIN project has three main components :

• the development and refinement of methods for the real-time analysis and feedback of fMRI data and combination with other imaging modalities (WP2),
• the adaptation of fMRI mapping techniques to localise disease-relevant networks and development of protocols for their self-regulation through neurofeedback (WP3)
• the assessment of feasibility and clinical effects in several mental, metabolic and neurological disorders (autism spectrum disorders, alcohol addiction, post-traumatic stress disorder, childhood anxiety disorders, binge-eating disorder, obesity, depression) (WP4).
• The consortium will also explore the potential transfer of imaging feed)back training into everyday settings through ambulatory and assistive technologies such as electroencephalography and near infrared-spectroscopy(NIRS) and gaming (WP5).

Finally BRAINTRAIN will engage with potential users of these technologies through several workshops, liaise with regulatory authorities and disseminate findings to the academic and user communities in WP6.

BRAINTRAIN will improve and adapt the methods of real-time fMRI NF for clinical use, including the combination with electroencephalography and the development of standardized procedures for the mapping of brain networks that can be targeted with NF. Its core component will be the exploration of the efficacy of fMRI-NF in selected mental and neurodevelopmental disorders that involve motivational, emotional and social neural systems targetable with this technique and pose major public health problems because of their prevalence and hitherto limited treatment options. The development and evaluation of fMRI-NF protocols for these disorders is thus particularly promising on both neurobiological and clinical grounds.

Furthermore, it has the potential of being cost-effective as well. Current therapeutic approaches require the presence of a therapist, and the real life transfer of imaging based neurofeedback approaches piloted within BRAINTRAIN would help reduce costs and aid generalization of therapies.

We also expect that the health economic evaluation of the new intervention and prevention strategies developed within BRAINTRAIN will suggest ways of reducing wider costs associated with these disorders, such as those associated with absence from work and early retirement, and thus respond to urgent societal needs.